Conjugation Site Heterogeneity Causes Variable Electrostatic Properties in Fc Conjugates
نویسندگان
چکیده
منابع مشابه
Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates.
Immunoconjugates, including antibody-drug conjugates and Fc-conjugates, represent a rapidly growing class of therapeutics undergoing clinical development. Despite their growing popularity, the high intrinsic heterogeneity of immunoconjugates often complicates the development process and limits their widespread application. In particular, immunoconjugate charge variants exhibit markedly differen...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2013
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc4000564